Barta Lab

Majlinda Lako, Newcastle University, Newcastle upon Tyne, UK

  • Volpato V, Smith J, Sandor C, Ried JS, Baud A, Handel A, Newey SE, Wessely F, Attar M, Whiteley E, Chintawar S, Verheyen A, Barta T, Lako M, Armstrong L, Muschet C, Artati A, Cusulin C, Christensen K, Patsch C, Sharma E, Nicod J,
    Brownjohn P, Stubbs V, Heywood WE, Gissen P, De Filippis R, Janssen K, Reinhardt P, Adamski J, Royaux I, Peeters PJ, Terstappen GC, Graf M, Livesey FJ, Akerman CJ, Mills K, Bowden R, Nicholson G, Webber C, Cader MZ, Lakics V. Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study. Stem Cell Reports. 2018 Oct 9;11(4):897-911. doi: 10.1016/j.stemcr.2018.08.013. Epub 2018 Sep 20. PMID: 30245212; PMCID: PMC6178242.
  • Melguizo-Sanchis D, Xu Y, Taheem D, Yu M, Tilgner K, Barta T, Gassner K, Anyfantis G, Wan T, Elango R, Alharthi S, El-Harouni AA, Przyborski S, Adam S, Saretzki G, Samarasinghe S, Armstrong L, Lako M. iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors. Cell Death Dis. 2018 Jan 26;9(2):128. doi:
    10.1038/s41419-017-0141-1. PMID: 29374141; PMCID: PMC5833558.
  • Meader E, Barta T, Melguizo-Sanchis D, Tilgner K, Montaner D, El-Harouni AA, Armstrong L, Lako M. Pluripotent Stem Cell-Derived Hematopoietic Progenitors Are Unable to Downregulate Key Epithelial-Mesenchymal Transition-Associated miRNAs. Stem Cells. 2018 Jan;36(1):55-64. doi: 10.1002/stem.2724. Epub 2017 Oct 27. PMID: 29047185; PMCID: PMC5765482.
  • Barta T, Peskova L, Collin J, Montaner D, Neganova I, Armstrong L, Lako M. Brief Report: Inhibition of miR-145 Enhances Reprogramming of Human Dermal Fibroblasts to Induced Pluripotent Stem Cells. Stem Cells. 2016 Jan;34(1):246-51. doi: 10.1002/stem.2220. Epub 2015 Oct 9. PMID: 26418476; PMCID: PMC4982107.
  • Jiang Y, Habibollah S, Tilgner K, Collin J, Barta T, Al-Aama JY, Tesarov L, Hussain R, Trafford AW, Kirkwood G, Sernagor E, Eleftheriou CG, Przyborski S, Stojković M, Lako M, Keavney B, Armstrong L. An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes. Stem Cells Transl Med. 2014 Apr;3(4):416-23. doi: 10.5966/sctm.2013-0105. Epub 2014 Mar 3. PMID:24591732; PMCID: PMC3973710.

Marek Mraz, CEITEC, Czech Republic

  • Peskova L, Cerna K, Oppelt J, Mraz M, Barta T. Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts. Sci Rep. 2019 Oct 31;9(1):15759. doi: 10.1038/s41598-019-52294-3. PMID: 31673026; PMCID: PMC6823439.
  • Dolezalova D, Mraz M, Barta T, Plevova K, Vinarsky V, Holubcova Z, Jaros J,
    Dvorak P, Pospisilova S, Hampl A. MicroRNAs regulate p21(Waf1/Cip1) protein expression and the DNA damage response in human embryonic stem cells. Stem Cells. 2012 Jul;30(7):1362-72. doi: 10.1002/stem.1108. PMID: 22511267.

Peter Kollár, Faculty of Pharmacy, Masaryk University, Czech Republic

  • Kollar P, Bárta T, Keltošová S, Trnová P, Müller Závalová V, Šmejkal K, Hošek
    J, Fedr R, Souček K, Hampl A. Flavonoid 4'-O-Methylkuwanon E from Morus alba Induces the Differentiation of THP-1 Human Leukemia Cells. Evid Based Complement Alternat Med. 2015;2015:251895. doi: 10.1155/2015/251895. Epub 2015 Feb 9. PMID: 25737734; PMCID: PMC4337268.
  • Kollar P, Bárta T, Hošek J, Souček K, Závalová VM, Artinian S, Talhouk R,
    Smejkal K, Suchý P Jr, Hampl A. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evid Based Complement Alternat Med. 2013;2013:350519. doi: 10.1155/2013/350519. Epub 2013 May 20. PMID: 23762124; PMCID: PMC3671669.
  • Kollár P, Bárta T, Závalová V, Smejkal K, Hampl A. Geranylated flavanone
    tomentodiplacone B inhibits proliferation of human monocytic leukaemia (THP-1) cells. Br J Pharmacol. 2011 Apr;162(7):1534-41. doi:
    10.1111/j.1476-5381.2010.01171.x. PMID: 21175584; PMCID: PMC3057291.

Vladimír Rotrekl, Faculty of Medicine, Masaryk University, Czech Republic

  • Kohutova A, Raška J, Kruta M, Seneklova M, Barta T, Fojtik P, Jurakova T,
    Walter CA, Hampl A, Dvorak P, Rotrekl V. Ligase 3-mediated end-joining maintains genome stability of human embryonic stem cells. FASEB J. 2019 Jun;33(6):6778-6788. doi: 10.1096/fj.201801877RR. Epub 2019 Feb 26. PMID: 30807703.
  • Krutá M, Bálek L, Hejnová R, Dobšáková Z, Eiselleová L, Matulka K, Bárta T,
    Fojtík P, Fajkus J, Hampl A, Dvořák P, Rotrekl V. Decrease in abundance of
    apurinic/apyrimidinic endonuclease causes failure of base excision repair in culture-adapted human embryonic stem cells. Stem Cells. 2013 Apr;31(4):693-702. doi: 10.1002/stem.1312. PMID: 23315699.

Leonora Buzanska, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

  • Augustyniak J, Zychowicz M, Podobinska M, Barta T, Buzanska L. Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells. Acta Neurobiol Exp (Wars). 2014;74(4):373-82. PMID:25576968.

Pavel Krejčí, Faculty of Medicine, Masaryk University, Czech Republic

  • Paige Taylor S, Kunova Bosakova M, Varecha M, Balek L, Barta T, Trantirek L,
    Jelinkova I, Duran I, Vesela I, Forlenza KN, Martin JH, Hampl A; University of
    Washington Center for Mendelian Genomics, Bamshad M, Nickerson D, Jaworski ML, Song J, Ko HW, Cohn DH, Krakow D, Krejci P. An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome. Hum Mol Genet. 2016 Sep 15;25(18):3998-4011. doi: 10.1093/hmg/ddw240. Epub 2016 Jul 27. PMID: 27466187; PMCID: PMC5291234.
  • Csukasi F, Duran I, Barad M, Barta T, Gudernova I, Trantirek L, Martin JH,
    Kuo CY, Woods J, Lee H, Cohn DH, Krejci P, Krakow D. The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling. Sci Transl Med. 2018 Sep 19;10(459):eaat9356. doi: 10.1126/scitranslmed.aat9356. PMID: 30232230; PMCID: PMC7529349.
  • Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernova I, Fafilek B, Barta T, Basheer N, Abraham SP, Balek L, Tomanova M, Fialova Kucerova J, Bosak J, Potesil D, Zieba J, Song J, Konik P, Park S, Duran I, Zdrahal Z, Smajs D, Jansen G, Fu Z, Ko HW, Hampl A, Trantirek L, Krakow D, Krejci P. Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4316-4325. doi: 10.1073/pnas.1800338116. Epub 2019 Feb 19. PMID: 30782830; PMCID: PMC6410813.
  • Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I,
    Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ; University of Washington Center for Mendelian Genomics, Rohatgi R, Cohn DH, Krakow D, Krejci P. Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. EMBO Mol Med. 2020 Nov 6;12(11):e11739. doi:10.15252/emmm.201911739. Epub 2020 Oct 14. PMID: 33200460; PMCID: PMC7645380.

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