Gametogenesis and Early Embryo Development

Zuzana Holubcová
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PharmDr. Zuzana Holubcová, Ph.D. is an Assistant Professor, senior lecturer, and Principal Investigator at the Department of Histology and Embryology, Faculty of Medicine, Masaryk University in Brno, Czech Republic. She obtained her Master’s degree and the professional doctoral degree (PharmDr.) in Pharmacy from the University of Veterinary and Pharmaceutical Sciences Brno and completed her Ph.D. in Medical Biology at Masaryk University, where she investigated genetic instability in human embryonic stem cells. She subsequently conducted postdoctoral research in the Melina Schuh laboratory at the MRC Laboratory of Molecular Biology in Cambridge, UK, where she studied mouse oocyte maturation and pioneered live-cell imaging approaches to analyse chromosome segregation in human oocytes.

The work of her research group focuses on oocyte biology and early embryonic development, particularly the mechanisms underlying oocyte maturation and the origins of embryonic aneuploidy. Her overarching research goal is to understand the biological basis of human infertility and to translate this knowledge into improved reproductive outcomes and fertility treatments. In line with this translational focus, she serves as Scientific Advisor to the assisted reproduction clinic Reprofit International, facilitating the application of basic research findings in clinical practice.

In addition to her research activities, Dr. Holubcová serves as a senior lecturer and Deputy Head of the Clinical Embryology study program at the Faculty of Medicine, contributing to the training of future specialists in reproductive medicine.

Dr. Holubcová is an active member of the European Society of Human Reproduction and Embryology (ESHRE), where she served as the elected national representative from 2020 to 2023. Her work has been recognized by multiple awards, including the Neuron Impuls Award in Medicine, the L’Oréal-UNESCO Women in Science Award, the ESHRE Basic Science Award at the ESHRE Annual Meeting 2015, and the MUNI Scientist Award.

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