WELCOME TO

Laboratory of Cilia and Centrosome Biology

We are enthusiastic bunch of cell biologists tackling the structure and function of primary cilia and centrosomes in human cells for living.

Primary cilia are antenna–like organelles present on cell surface. They are templated by the older ("mother") centriole in non-dividing cells. In dividing cells, centrioles form the centrosome - mitotic spindle organizer that facilitates the cell division. Correctly tuned signaling orchestrated by primary cilia (e.g. Hedgehog pathway) is essential both for embryo development and adult tissue homeostasis. Deregulation of either cilia or centrosome biology often leads to disease. Successful treatment of such diseases calls for better understanding of their origin.

We have expertise in molecular and cell biology approaches, including proteomics, gene editing, stem cells, super-resolution microscopy, live cell imaging microscopy, and biochemistry.

For a complete list of publications go to PubMed

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contact us at:

 

Lukas Cajanek
cajanek@med.muni.cz

Department of Histology and Embryology
Masaryk University, Faculty of Medicine
Kamenice 3, building F01
625 00 Brno
Czech Republic

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Learn more about us at www.cajaneklab.com

RESEARCH

Cilia formation and function from the perpspective of distal appendages: focus on TTBK2

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Interplay between the regulations of cell cycle and ciliogenesis

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Modelling the loss of ciliary function using human pluripotent stem cells

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