Petr Vaňhara Research group: Tissue plasticity and regeneration
Our lab primarily focuses on the role of endoplasmic reticulum (ER) in plasticity and regeneration of normal and diseased epithelial tissues. We investigate how the canonical and non-canonical ER signaling alters tissue response to various form of cell stress, and how this response alters tissue morphology and functions.
We have introduced dedicated tissue models to reveal fine mechanisms of tissue regeneration and plasticity. In particular, it is the ovarian surface epithelium, endometrial stromal cells or lung cells derived from pluripotent stem cells. To address research questions we use the state-of-the-art microscopy including super resolution and live-cell imaging and range of molecular, bioanalytical and histological methods and tools. In addition, we develop bioanalytical techniques for cell profiling and phenotyping using whole-cell mass spectrometry and chemometrics.